DHT Blocker

herbal and mineral formula


DHT Blocker is a herbal and mineral formula designed to help treat:


1. Male pattern hair loss - there is some evidence that the use of these supplements will have an extra effect on top of drug treatment.


  1. 1.Male lower urinary tract symptoms due to benign prostatic hypertrophy - strong evidence that the use of these supplements is as effective as Proscar and Flomaxtra.







A herbal and mineral complex designed to block the production and effects of DHT (dihydrotestosterone) in men and women. DHT has been shown to be a causative mechanism in:

• Male pattern hair loss.

• Male prostate enlargement, benign prostatic hyperplasia (BPH).


The ingredients in DHT BLOCKER have been chosen on the basis of the scientific evidence in support of their effectiveness.









The Saw palmetto plant is a native of Southern California. The berries have been shown to inhibit the enzyme 5 alpha reductase (5AR). This is the enzyme which converts testosterone to DHT. Saw palmetto also acts against the formation of DHT in other ways.

Saw palmetto has been shown to decrease 5AR activity by 32% and reduce serum DHT by 40%1.

One study showed Saw palmetto (200mg of 95% extract, equivalent of 400mg of 45% extract) in combination with beta sitosterol regrew hair in 60% of male hair loss sufferers. There is no specific data relating to female hair loss, although since DHT is involved in female pattern loss and the DHT blocker Saw palmetto has been shown to reduce DHT it seems very likely that it will help. The study to prove this has yet to be done.

Saw palmetto has been proven to reduce the symptoms of mild to moderate BPH by a level equal to the drug finasteride (Proscar2). It is not enough to avoid an operation if that is what is needed but enough to really help if your problem is at the milder end.

It is important to use saw palmetto extract and not just the cheaper berries to ensure effective amounts of the active ingredients.


Safety of Saw palmetto


This is not a document that asserts that herbal medicines have no side effects, that somehow they are “natural” and therefore benign. Herbs are harvested, stored and transported like any other agricultural product. They are then processed and packaged in large factories (all of them). They are as far away from their natural state as a packet of Rice Bubbles is from the rice paddy field.

All medicines, herbal or otherwise, have side effects. Some have more than others but in general the stronger the treatment the more severe the side effects. Saw palmetto is generally well tolerated, the only side effect known being some mild nausea and gastrointestinal upset in some individuals. There are no known drug interactions and no known change to PSA or other lab test results.

However, it is essential that no DHT blocking agents should be used if there is a possibility of pregnancy. DHT has been shown to be essential for the normal sexual development of the male fetus. The drug finasteride (in Propecia and Proscar) is known to affect this development. While no-one knows for sure whether Saw palmetto or the other effective herbal DHT blockers have the same effect, it pays to not take any chances.







While saw palmetto has been extensively studied, there is less evidence to support the use of the extract from the bark of the tree Pygeum africanum. Nevertheless, this extract is actually used more frequently than saw palmetto in Italy and Germany, the two countries with the most sophisticated herbal medicine industries.

The only medical studies have been performed in the area of BPH. The Cochrane Collaberation is the world’s largest international independent review organisation. This group of doctors and specialists work to provide unbiased advice independent of the large drug companies. Their review found that pygeum africanum is well tolerated, cheaper than many prescription medicines used for BPH, and provides moderate relief from the urinary problems caused by an enlarged prostate3.

Safety of Pygeum africanum


No side effects or drug interactions have been found. The biggest issue with pygeum is the effects of it’s popularity. The tree is now classed as threatened due to unfortunate popularity of unsustainable harvesting and import of the bark now requires CITES certification to ensure sustainability. Our FDA approved US manufacturer complies with all the necessary regulations in this area.





The plant sterols are most famous for their use in cholesterol lowering margarines. Beta sitosterol is the most abundant. One study shows a positive effect on hair loss in males in combination with Saw Palmetto1. No known safety issues.






The effects of stinging nettle are well documented at the people’s pharmacy (www.peoplespharmacy.com). While not specifically studied with regard to hair loss there is laboratory evidence of ability to reduce DHT levels and clinical evidence of reduction in the symptoms of BPH. It is important to use the more effective root extract and not the weaker nettle leaf.


Safety of Stinging nettle root

Stinging nettle root can increase the potassium level of people with impaired renal (kidney) function and should be used with caution by those with kidney impairment.






Zinc works in multiple ways to inhibit 5 alpha reductase and reduce DHT levels. It requires adequate levels of vitamin B6 to work well so it is synergistic to maintain an adequate intake of each nutrient. In addition vitamin B6 reduces the action of the DHT receptor after activation, reducing DHT in amother way6.


Studies show that the picolinate form of zinc is the most effective at raising the bodies zinc levels5. Active individuals will frequently have lower levels of zinc.


Safety of Zinc and Vitamin B6


Zinc has been shown to be safe in doses over 50mg a day and there are no safety issues with vitamin B6.







Deficiency in biotin leads to hair loss. While this is very unlikely unless a person survives on egg whites alone. Extra doses of biotin do, however help brittle nails and split ends so it seems prudent to ensure that intake of this very safe vitamin is adequate.







1. Saw Palmetto—Saw palmetto, or Serenoa repens, is an herbal remedy that is processed from fruit of the American dwarf pine tree.42 It often is used to treat benign prostatic hypertrophy because of its ability to inhibit 5α-reductase levels by 32% without affecting testosterone levels in men. Extracts of saw palmetto also have been shown to have a partial antagonistic affect on testosterone receptors. It is most likely that these 2 actions led to saw palmetto being used as a hair loss remedy. Saw palmetto is believed to be a safe herbal supplement, with a primary side effect of mild gastrointestinal distress. Also, clinical trials conducted in human patients showed that consumption of saw palmetto supplements did not result in any clinically significant alterations in laboratory parameters. Saw palmetto has no known drug interactions. The cost of this supplement varies by manufacturer. One double-blind placebo-controlled study examined saw palmetto’s effect on AGA. In this study, researchers studied the efficacy of a softgel containing β-sitosterol 50 mg and saw palmetto 200 mg extract (components of the HairGenesisTM Softgels discussed later) versus placebo in treating AGA. They found that 60% of patients taking the active softgel rated their hair growth as improved from baseline as opposed to only 10% of the patients taking placebo. However, this study had a limited patient population and also concurrently tested β-sitosterol, so any improvement cannot be attributed to saw palmetto alone. 


Hair Loss Remedies—Separating Fact From Fiction. Ilian Bandaranayake, BA; Paradi Mirmirani, MD Cutis. 2004;73:107-114.



2. Serenoa repens, a herbal medicine, provides mild to moderate improvement in urinary symptoms and flow measures for men with enlarged prostate glands (benign prostatic hyperplasia). An enlarged prostate gland, benign prostatic hyperplasia (BPH), can interfere with urination, increasing the frequency and urge, or cause problems emptying the bladder. Surgery and drugs can be used to try to treat BPH. However, using herbal medicines to try to relieve BPH symptoms is common. Serenoa repens is a popular herbal medicine for BPH. The review found that serenoa repens was well tolerated, providing mild to moderate improvement in urinary symptoms and flow measures. These improvements were comparable to those seen in men taking a prescription drug, finasteride, for BPH. Research into long-term effects of serenoa repens is needed.


Serenoa repens for benign prostatic hyperplasia. Wilt T, Ishani A, Mac Donald R http://www.cochrane.org/reviews/en/ab001423.html



3.  Extracts from the African prune tree (Pygeum africanum) may be able to help relieve urinary symptoms caused by enlarged prostate (benign prostatic hyperplasia). Benign prostatic hyperplasia (BPH), enlargement of the prostate gland, is common in older men. An enlarged prostate can interfere with urination, increasing the frequency and urge, or causing problems emptying the bladder. Both surgery and drugs are used to try to treat BPH. However, using herbal medicines to try to relieve the symptoms of BPH is becoming common. Pygeum africanum is one of several popular herbal remedies for BPH. The review found that pygeum africanum is well tolerated, cheaper than many prescription medicines used for BPH, and provides moderate relief from the urinary problems caused by an enlarged prostate


Pygeum africanum for benign prostatic hyperplasia. Wilt T, Ishani A, Mac Donald R, Rutks I, Stark G. http://www.cochrane.org/reviews/en/ab001044.html


4. Several herbal remedies taken as laxatives contain active compounds called anthraquinones. The laxative herbs senna (Senna alexandria), cascara sagrada (Rhamnus purshiana), and rhubarb (Rheum officinale) can lead to electrolyte imbalance especially hypokalemia (Westendorf, 1993). Another herbal supplement of possible concern to the renal patient is noni juice. Juice made from the noni fruit (Morinda citrifolia) could contribute to the development of hyperkalemia due to its high content of potassium (56.3 mEq/L) (Mueller, Scott, Sowinski, & Prag, 2000). Dandelion (Taraxacum officinale), stinging nettle (Urtica dioica), horsetail (Equisetum arvense), and alfalfa (Medicago sativa) are also high in potassium (Leung & Foster, 1996). Plants high in oxalic acid such as rhubarb (Rheum officinale) may increase the formation of kidney stones (Leung & Foster, 1996). There has also been a report of acute oxalate nephropathy following ingestion of star fruit (Averrhoa carambola) (Chen, Fang, Chou, Wang, & Chung, 2001).





5.The comparative absorption of zinc after oral administration of three different complexed forms was studied in 15 healthy human volunteers in a double-blind four-period crossover trial. The individuals were randomly divided into four groups. Each group rotated for four week periods through a random sequence of oral supplementation including: zinc picolinate, zinc citrate, and zinc gluconate (equivalent to 50 mg elemental zinc per day) and placebo. Zinc was measured in hair, urine, erythrocyte and serum before and after each period. At the end of four weeks hair, urine and erythrocyte zinc levels rose significantly (p less than 0.005, p less than 0.001, and p less than 0.001) during zinc picolinate administration. There was no significant change in any of these parameters from zinc gluconate, zinc citrate or placebo administration. There was a small, insignificant rise in serum zinc during zinc picolinate, zinc citrate and placebo supplementation. The results of this study suggest that zinc absorption in humans can be improved by complexing zinc with picolinic acid.


Barrie SA, Wright JV, Pizzorno JE, Kutter E, Barron PC. Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans. Agents Actions. 1987 Jun;21(1-2):223-8.




6. Vitamin B6 reduces by 35-40% the extent of protein synthesis observed after androgen receptor activation.

Allgood VE, Cidlowski JA. Vitamin B6 modulates transcriptional activation by multiple members of the steroid hormone receptor superfamily.


J Biol Chem 1992; 267: 3819-24. cited in http://dermatology.cdlib.org/DOJvol4num1/original/jankovi.html